General form of registration statement for all companies including face-amount certificate companies

Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate (Detail)

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Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Effective Income Tax Rate Reconciliation, Percent [Abstract]    
U.S. federal tax benefit at statutory rate 21.00% 21.00%
State income taxes, net of federal benefit 3.50% 2.50%
Non-deductible expenses and other (0.90%) 0.10%
Research and development credits 5.40% (0.80%)
Foreign rate differential (0.60%) 1.10%
Change in valuation allowance, net (29.60%) (25.00%)
Effective tax rate (1.20%) (1.10%)